Not to be confused with the Big Purple Space Amoeba, a similar evil purple slimy thing.
The Surface-Living Intelligent Multiplying Endolith, or S.L.I.M.E., is a single consciousness that takes the form of oozing, glutinous patches of mucous that are spreading rapidly throughout the Milky Way galaxy by concealing itself within meteors or spacecraft. It hides in cracks underground, then rises to the surface and rampages across planets, growing in size as it goes. Whenever it comes across a living entity, S.L.I.M.E. devours its nutrients and moves on, leaving only a sticky gunk in its place.
Combatting S.L.I.M.E. is a top priority of the Intergalactic Council, the Meteor Police, and the Gray Federation. The former is intently studying Humans, who have something in their genetic makeup that prevents S.L.I.M.E. from growing and overpowering them. However, it still is able to exert a limited hypnotic influence over them, as was the case with the Edison family in the Maniac Mansion incident.