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Maniac Mansion was a mansion on planet Earth. It was the home of Dr. Fred Edison, his wife Edna, their son Edwin, his dead cousin Ted, and their servants Green Tentacle and Purple Tentacle. Though they had always been a tad eccentric, it received its name after the nearby crash of a meteor infected with SLIME caused them to go stark-raving bonkers.

The mansion was powered by nuclear energy. The pool was full of radioactive waste.

College cheerleader Sandy Pantz was kidnapped by Dr. Edison to this location to have her brains eaten by the meteor. She was rescued by her boyfriend David Miller and several of his friends, as well as the timely intervention of the Meteor Police.